Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy

Impaired glucose metabolism, decreased levels of thiamine and its phosphate esters, and reduced activity of thiamine-dependent enzymes, such as pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and transketolase occur in Alzheimer’s disease (AD). Thiamine deficiency exacerbates amyloid beta...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Tapias, Victor, Jainuddin, Shari, Ahuja, Manuj, Stack, Cliona, Elipenahli, Ceyhan, Vignisse, Julie, Gerges, Meri, Starkova, Natalia, Xu, Hui, Starkov, Anatoly A, Bettendorff, Lucien, Hushpulian, Dmitry M, Smirnova, Natalya A, Gazaryan, Irina G, Kaidery, Navneet A, Wakade, Sushama, Calingasan, Noel Y, Thomas, Bobby, Gibson, Gary E, Dumont, Magali, Beal, M Flint
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077804/
https://ncbi.nlm.nih.gov/pubmed/29860433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy201
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