Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing

The precise correction of genetic mutations at the nucleotide level is an attractive permanent therapeutic strategy for human disease. However, despite significant progress, challenges to efficient and accurate genome editing persist. Here, we report a genome editing platform based upon a class of h...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Smith, Laura J., Wright, Jason, Clark, Gabriella, Ul-Hasan, Taihra, Jin, Xiangyang, Fong, Abigail, Chandra, Manasa, St Martin, Thia, Rubin, Hillard, Knowlton, David, Ellsworth, Jeff L., Fong, Yuman, Wong, Kamehameha K., Chatterjee, Saswati
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077703/
https://ncbi.nlm.nih.gov/pubmed/30018062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802343115
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