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Interrupted reprogramming into induced pluripotent stem cells does not rejuvenate human mesenchymal stromal cells

Replicative senescence hampers application of mesenchymal stromal cells (MSCs) because it limits culture expansion, impairs differentiation potential, and hinders reliable standardization of cell products. MSCs can be rejuvenated by reprogramming into induced pluripotent stem cells (iPSCs), which is...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Göbel, Carolin, Goetzke, Roman, Eggermann, Thomas, Wagner, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076311/
https://ncbi.nlm.nih.gov/pubmed/30076334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30069-6
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