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Identification and characterization of TP53 gene Allele Dropout in Li-Fraumeni syndrome and Oral cancer cohorts

Allele Drop out (ADO) arising from non-amplification of one allele may produce false negative result and impact clinical management. In cancer, germline and somatic genetic analysis is being increasingly used but the prevalence, nature and implications of ADO has not been studied in any cohort. In a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Haque, Mohammed Moquitul, Kowtal, Pradnya, Sarin, Rajiv
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076284/
https://ncbi.nlm.nih.gov/pubmed/30076369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30238-7
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