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Allele-Specific Wild-Type TP53 Expression in the Unaffected Carrier Parent of Children with Li-Fraumeni Syndrome
Li-Fraumeni Syndrome (LFS) is an autosomal dominant disorder where an oncogenic TP53 germline mutation is passed from parent to child. p53 is a key tumor suppressor regulating cell cycle arrest in response to DNA damage. Paradoxically, some mutant TP53 carriers remain unaffected, while their childre...
Gorde:
| Argitaratua izan da: | Cancer Genet |
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| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5347445/ https://ncbi.nlm.nih.gov/pubmed/28279309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cancergen.2017.01.001 |
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