Presenilin mutations deregulate mitochondrial Ca(2+) homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans

Mitochondrial dysfunction and subsequent metabolic deregulation is observed in neurodegenerative diseases and aging. Mutations in the presenilin (PSEN) encoding genes (PSEN1 and PSEN2) cause most cases of familial Alzheimer’s disease (AD); however, the underlying mechanism of pathogenesis remains un...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Sarasija, Shaarika, Laboy, Jocelyn T, Ashkavand, Zahra, Bonner, Jennifer, Tang, Yi, Norman, Kenneth R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2018
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6075864/
https://ncbi.nlm.nih.gov/pubmed/29989545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33052
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