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A γ-Secretase Independent Role for Presenilin in Calcium Homeostasis Impacts Mitochondrial Function and Morphology in Caenorhabditis elegans

Mutations in the presenilin (PSEN) encoding genes (PSEN1 and PSEN2) occur in most early onset familial Alzheimer’s Disease. Despite the identification of the involvement of PSEN in Alzheimer’s Disease (AD) ∼20 years ago, the underlying role of PSEN in AD is not fully understood. To gain insight into...

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Bibliografische gegevens
Gepubliceerd in:Genetics
Hoofdauteurs: Sarasija, Shaarika, Norman, Kenneth R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Genetics Society of America 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676538/
https://ncbi.nlm.nih.gov/pubmed/26500256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.115.182808
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