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Presenilin mutations deregulate mitochondrial Ca(2+) homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans

Mitochondrial dysfunction and subsequent metabolic deregulation is observed in neurodegenerative diseases and aging. Mutations in the presenilin (PSEN) encoding genes (PSEN1 and PSEN2) cause most cases of familial Alzheimer’s disease (AD); however, the underlying mechanism of pathogenesis remains un...

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Vydáno v:eLife
Hlavní autoři: Sarasija, Shaarika, Laboy, Jocelyn T, Ashkavand, Zahra, Bonner, Jennifer, Tang, Yi, Norman, Kenneth R
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6075864/
https://ncbi.nlm.nih.gov/pubmed/29989545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33052
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