Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy

Merosin-deficient congenital muscular dystrophy type 1A (MDC1A) is a dramatic neuromuscular disease in which crippling muscle weakness is evident from birth. Here, we use the dy(W) mouse model for human MDC1A to trace the onset of the disease during development in utero. We find that myotomal and pr...

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Bibliografske podrobnosti
izdano v:Hum Mol Genet
Main Authors: Nunes, Andreia M., Wuebbles, Ryan D., Sarathy, Apurva, Fontelonga, Tatiana M., Deries, Marianne, Burkin, Dean J., Thorsteinsdóttir, Sólveig
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6075618/
https://ncbi.nlm.nih.gov/pubmed/28334989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx083
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