High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington’s disease CAG knock-in mice across multiple genetic backgrounds

Huntington’s disease is a dominantly inherited neurodegenerative disease caused by the expansion of a CAG repeat in the HTT gene. In addition to the length of the CAG expansion, factors such as genetic background have been shown to contribute to the age at onset of neurological symptoms. A central c...

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Detaylı Bibliyografya
Yayımlandı:Hum Mol Genet
Asıl Yazarlar: Ament, Seth A., Pearl, Jocelynn R., Grindeland, Andrea, St. Claire, Jason, Earls, John C., Kovalenko, Marina, Gillis, Tammy, Mysore, Jayalakshmi, Gusella, James F., Lee, Jong-Min, Kwak, Seung, Howland, David, Lee, Min Young, Baxter, David, Scherler, Kelsey, Wang, Kai, Geman, Donald, Carroll, Jeffrey B., MacDonald, Marcy E., Carlson, George, Wheeler, Vanessa C., Price, Nathan D., Hood, Leroy E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6075528/
https://ncbi.nlm.nih.gov/pubmed/28334820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx006
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