High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington’s disease CAG knock-in mice across multiple genetic backgrounds

Huntington’s disease is a dominantly inherited neurodegenerative disease caused by the expansion of a CAG repeat in the HTT gene. In addition to the length of the CAG expansion, factors such as genetic background have been shown to contribute to the age at onset of neurological symptoms. A central c...

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Publicado en:Hum Mol Genet
Autores principales: Ament, Seth A., Pearl, Jocelynn R., Grindeland, Andrea, St. Claire, Jason, Earls, John C., Kovalenko, Marina, Gillis, Tammy, Mysore, Jayalakshmi, Gusella, James F., Lee, Jong-Min, Kwak, Seung, Howland, David, Lee, Min Young, Baxter, David, Scherler, Kelsey, Wang, Kai, Geman, Donald, Carroll, Jeffrey B., MacDonald, Marcy E., Carlson, George, Wheeler, Vanessa C., Price, Nathan D., Hood, Leroy E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6075528/
https://ncbi.nlm.nih.gov/pubmed/28334820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx006
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