Cholesterol uptake and regulation in high-grade and lethal prostate cancers

Lethal prostate cancers have higher expression of squalene monooxygenase (SQLE), the second rate-limiting enzyme of cholesterol synthesis. Preclinical studies suggested that aberrant cholesterol regulators, receptors and transporters contribute to cholesterol accumulation uniformly. We assessed thei...

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Bibliographische Detailangaben
Veröffentlicht in:Carcinogenesis
Hauptverfasser: Stopsack, Konrad H, Gerke, Travis A, Andrén, Ove, Andersson, Swen-Olof, Giovannucci, Edward L, Mucci, Lorelei A, Rider, Jennifer R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6074871/
https://ncbi.nlm.nih.gov/pubmed/28595267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgx058
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