Intratumoral sterol-27-hydroxylase (CYP27A1) expression in relation to cholesterol synthesis and vitamin D signaling and its association with lethal prostate cancer

BACKGROUND: Higher intratumoral cholesterol synthesis is associated with a worse prognosis in prostate cancer. The vitamin D-regulated enzyme sterol-27-hydroxylase (CYP27A1) converts cholesterol to 27-hydroxycholesterol, potentially lowering intracellular cholesterol levels. We hypothesized that low...

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Veröffentlicht in:Cancer Epidemiol Biomarkers Prev
Hauptverfasser: Khan, Nabeela A., Stopsack, Konrad H., Allott, Emma H., Gerke, Travis, Giovannucci, Edward L., Mucci, Lorelei A., Kantoff, Philip W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548616/
https://ncbi.nlm.nih.gov/pubmed/30867220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-18-1083
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