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Efficient Lead Finding, Activity Enhancement and Preliminary Selectivity Control of Nuclear Receptor Ligands Bearing a Phenanthridinone Skeleton
Background: Nuclear receptors (NRs) are considered as potential drug targets because they control diverse biological functions. However, steroidal ligands for NRs have the potential to cross-react with other nuclear receptors, so development of non-steroidal NR ligands is desirable to obtain safer a...
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Publicado en: | Int J Mol Sci |
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Autores principales: | , , , , |
Formato: | Artigo |
Lenguaje: | Inglês |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6073568/ https://ncbi.nlm.nih.gov/pubmed/30021999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19072090 |
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