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Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative

BACKGROUND: The novel phenanthridinone derivative HA-719 has recently been identified as a highly potent and selective inhibitor of hepatitis C virus replication. To elucidate its mechanism of inhibition, we have isolated and analyzed a clone of hepatitis C virus replicon cells resistant to HA-719....

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Detalhes bibliográficos
Publicado no:Antivir Chem Chemother
Main Authors: Ito, Wataru, Toyama, Masaaki, Okamoto, Mika, Ikeda, Masanori, Watashi, Koichi, Wakita, Takaji, Hashimoto, Yuichi, Baba, Masanori
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890506/
https://ncbi.nlm.nih.gov/pubmed/27503576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040206616663956
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