Antiproliferative Properties of Newly Synthesized 19-Nortestosterone Analogs Without Substantial Androgenic Activity

19-Nortestosterone C-17 epimers with prominent antiproliferative properties have been previously described. In our present study, five novel 17α-19-nortestosterones (3−7) were synthesized to increase their beneficial biological activities with no associated undesired hormonal effects. The compounds...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Gyovai, András, Minorics, Renáta, Kiss, Anita, Mernyák, Erzsébet, Schneider, Gyula, Szekeres, András, Kerekes, Erika, Ocsovszki, Imre, Zupkó, István
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072853/
https://ncbi.nlm.nih.gov/pubmed/30100876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00825
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