Loss of glutamate signaling from the thalamus to dorsal striatum impairs motor function and slows the execution of learned behaviors

Parkinson’s disease (PD) is primarily associated with the degeneration of midbrain dopamine neurons, but it is now appreciated that pathological processes like Lewy-body inclusions and cell loss affect several other brain regions, including the central lateral (CL) and centromedian/parafascicular (C...

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Bibliografiske detaljer
Udgivet i:NPJ Parkinsons Dis
Main Authors: Melief, Erica J., McKinley, Jonathan W., Lam, Jonathan Y., Whiteley, Nicole M., Gibson, Alec W., Neumaier, John F., Henschen, Charles W., Palmiter, Richard D., Bamford, Nigel S., Darvas, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072777/
https://ncbi.nlm.nih.gov/pubmed/30083593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-018-0060-6
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