Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy

In patients with Charcot–Marie–Tooth disease 1A (CMT1A), peripheral nerves display aberrant myelination during postnatal development, followed by slowly progressive demyelination and axonal loss during adult life. Here, we show that myelinating Schwann cells in a rat model of CMT1A exhibit a develop...

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Publicado en:Nat Commun
Main Authors: Fledrich, R., Abdelaal, T., Rasch, L., Bansal, V., Schütza, V., Brügger, B., Lüchtenborg, C., Prukop, T., Stenzel, J., Rahman, R. U., Hermes, D., Ewers, D., Möbius, W., Ruhwedel, T., Katona, I., Weis, J., Klein, D., Martini, R., Brück, W., Müller, W. C., Bonn, S., Bechmann, I., Nave, K. A., Stassart, R. M., Sereda, M. W.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072747/
https://ncbi.nlm.nih.gov/pubmed/30072689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05420-0
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