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PTEN Regulates Non-Homologous End Joining by Epigenetic Induction of NHEJ1/XLF

DNA double-strand breaks (DSBs) are the most cytotoxic DNA lesions, and up to 90% of DSBs require repair by non-homologous end joining (NHEJ). Functional and genomic analyses of patient-derived melanomas revealed that PTEN loss is associated with NHEJ deficiency. In PTEN-null melanomas PTEN compleme...

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發表在:Mol Cancer Res
Main Authors: Sulkowski, Parker L., Scanlon, Susan E., Oeck, Sebastian, Glazer, Peter M.
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072556/
https://ncbi.nlm.nih.gov/pubmed/29739874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0581
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