Identification of Novel Response and Predictive Biomarkers to Hsp90 Inhibitors Through Proteomic Profiling of Patient-derived Prostate Tumor Explants

Inhibition of the heat shock protein 90 (Hsp90) chaperone is a promising therapeutic strategy to target expression of the androgen receptor (AR) and other oncogenic drivers in prostate cancer cells. However, identification of clinically-relevant responses and predictive biomarkers is essential to ma...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Mol Cell Proteomics
Autori principali: Nguyen, Elizabeth V., Centenera, Margaret M., Moldovan, Max, Das, Rajdeep, Irani, Swati, Vincent, Andrew D., Chan, Howard, Horvath, Lisa G., Lynn, David J., Daly, Roger J., Butler, Lisa M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072547/
https://ncbi.nlm.nih.gov/pubmed/29632047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000633
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