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Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion
The molecular chaperone Hsp90 is overexpressed in prostate cancer (PCa) and is responsible for the folding, stabilization and maturation of multiple oncoproteins, which are implicated in PCa progression. Compared to first-in-class Hsp90 inhibitors such as 17-allylamino-demethoxygeldanamycin (17-AAG)...
Enregistré dans:
| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5794796/ https://ncbi.nlm.nih.gov/pubmed/29391407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19871-4 |
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