Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion

The molecular chaperone Hsp90 is overexpressed in prostate cancer (PCa) and is responsible for the folding, stabilization and maturation of multiple oncoproteins, which are implicated in PCa progression. Compared to first-in-class Hsp90 inhibitors such as 17-allylamino-demethoxygeldanamycin (17-AAG)...

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Pubblicato in:Sci Rep
Autori principali: Armstrong, Heather K., Gillis, Joanna L., Johnson, Ian R. D., Nassar, Zeyad D., Moldovan, Max, Levrier, Claire, Sadowski, Martin C., Chin, Mei Yieng, Tomlinson Guns, Emma S., Tarulli, Gerard, Lynn, David J., Brooks, Douglas A., Selth, Luke A., Centenera, Margaret M., Butler, Lisa M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794796/
https://ncbi.nlm.nih.gov/pubmed/29391407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19871-4
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