Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion

The molecular chaperone Hsp90 is overexpressed in prostate cancer (PCa) and is responsible for the folding, stabilization and maturation of multiple oncoproteins, which are implicated in PCa progression. Compared to first-in-class Hsp90 inhibitors such as 17-allylamino-demethoxygeldanamycin (17-AAG)...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Armstrong, Heather K., Gillis, Joanna L., Johnson, Ian R. D., Nassar, Zeyad D., Moldovan, Max, Levrier, Claire, Sadowski, Martin C., Chin, Mei Yieng, Tomlinson Guns, Emma S., Tarulli, Gerard, Lynn, David J., Brooks, Douglas A., Selth, Luke A., Centenera, Margaret M., Butler, Lisa M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794796/
https://ncbi.nlm.nih.gov/pubmed/29391407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19871-4
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