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Tetrahydroquinolinone derivatives as potent P-glycoprotein inhibitors: design, synthesis, biological evaluation and molecular docking analysis

P-glycoprotein (P-gp) is a transmembrane efflux pump that has been associated with ineffective cancer chemotherapy and multidrug resistance (MDR). Chemical inhibitors of P-gp could have potential cancer therapeutic applications by preventing or reversing MDR. To exploit this, we designed twenty-five...

詳細記述

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書誌詳細
出版年:Medchemcomm
主要な著者: Ranjbar, S., Firuzi, O., Edraki, N., Shahraki, O., Saso, L., Khoshneviszadeh, M., Miri, R.
フォーマット: Artigo
言語:Inglês
出版事項: Royal Society of Chemistry 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072533/
https://ncbi.nlm.nih.gov/pubmed/30108713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00178a
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