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The synthesis, biological evaluation and structure–activity relationship of 2-phenylaminomethylene-cyclohexane-1,3-diones as specific anti-tuberculosis agents

The present study utilised whole cell based phenotypic screening of thousands of diverse small molecules against Mycobacterium tuberculosis H37Rv (M. tuberculosis) and identified the cyclohexane-1,3-dione-based structures 5 and 6 as hits. The selected hit molecules were used for further synthesis an...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Medchemcomm
Κύριοι συγγραφείς: Rather, Muzafar Ahmad, Lone, Ali Mohd, Teli, Bisma, Bhat, Zubair Shanib, Singh, Paramjeet, Maqbool, Mubashir, Shairgojray, Bashir Ahmad, Dar, Mohd Jamal, Amin, Shajrul, Yousuf, Syed Khalid, Bhat, Bilal A., Ahmad, Zahoor
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Royal Society of Chemistry 2017
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072485/
https://ncbi.nlm.nih.gov/pubmed/30108731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00350a
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