Synthesis and in vitro evaluation of substituted 3-cinnamoyl-4-hydroxy-pyran-2-one (CHP) in pursuit of new potential antituberculosis agents

Tuberculosis is an ever-evolving infectious disease that urgently needs new drugs. In the search for new antituberculosis agents, a library of 3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-ones (CHPs) (2a–2y) was synthesized and evaluated against a standard virulent laboratory strain of Mycobacterium tu...

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Bibliographic Details
Published in:Medchemcomm
Main Authors: Bhat, Zubair Shanib, Ul Lah, Hafiz, Rather, Muzafar Ahmad, Maqbool, Mubashir, Ara, Tabassum, Ahmad, Zahoor, Yousuf, Syed Khalid
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2017
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072353/
https://ncbi.nlm.nih.gov/pubmed/30108910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00366h
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