The synthesis, biological evaluation and structure–activity relationship of 2-phenylaminomethylene-cyclohexane-1,3-diones as specific anti-tuberculosis agents

The present study utilised whole cell based phenotypic screening of thousands of diverse small molecules against Mycobacterium tuberculosis H37Rv (M. tuberculosis) and identified the cyclohexane-1,3-dione-based structures 5 and 6 as hits. The selected hit molecules were used for further synthesis an...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Rather, Muzafar Ahmad, Lone, Ali Mohd, Teli, Bisma, Bhat, Zubair Shanib, Singh, Paramjeet, Maqbool, Mubashir, Shairgojray, Bashir Ahmad, Dar, Mohd Jamal, Amin, Shajrul, Yousuf, Syed Khalid, Bhat, Bilal A., Ahmad, Zahoor
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072485/
https://ncbi.nlm.nih.gov/pubmed/30108731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00350a
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