A peptide inhibitor of antibody-dependent cell-mediated cytotoxicity against EGFR/folate receptor-α double positive cells

Antibody-dependent cell-mediated cytotoxicity (ADCC) is caused by natural killer (NK) cells upon recognition of antigen-bound IgG via FcγRIIIa. This mechanism is crucial for cytolysis of pathogen-infected cells and monoclonal antibody (mAb)-mediated elimination of cancer cells. However, there is con...

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Publicat a:Medchemcomm
Autors principals: Sasaki, Koichi, Miyashita, Yoshiki, Asai, Daisuke, Funamoto, Daiki, Sato, Kazuki, Yamaguchi, Yoko, Mishima, Yuji, Iino, Tadafumi, Takaishi, Shigeo, Nagano, Jun, Kishimura, Akihiro, Mori, Takeshi, Katayama, Yoshiki
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2018
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072457/
https://ncbi.nlm.nih.gov/pubmed/30108967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00010g
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