Novel (99m)Tc labelled complexes with 2-nitroimidazole isocyanide: design, synthesis and evaluation as potential tumor hypoxia imaging agents

Radiolabelled 2-nitroimidazoles have been used for imaging hypoxia. With the aim of developing novel (99m)Tc radiotracers for imaging hypoxia, four novel 2-nitroimidazole isocyanide derivatives (2a, 2b, 2c, and 2d) were synthesized and radiolabelling was carried out for preparing their corresponding...

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Bibliographic Details
Published in:Medchemcomm
Main Authors: Ruan, Qing, Zhang, Xuran, Lin, Xiao, Duan, Xiaojiang, Zhang, Junbo
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2018
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072354/
https://ncbi.nlm.nih.gov/pubmed/30108988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00146d
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