Novel (99m)Tc-labelled complexes with thymidine isocyanide: radiosynthesis and evaluation as potential tumor imaging tracers

A novel thymidine isocyanide (CN-TdR) functionalized at the N3 position of thymidine was synthesized and then radiolabelled with (99m)Tc(i) and [(99m)Tc(i)(CO)(3)](+) cores to produce [(99m)Tc(CN-TdR)(6)](+) and [(99m)Tc(CO)(3)(CN-TdR)(3)](+), respectively. Both of them were prepared with high radio...

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Udgivet i:Medchemcomm
Main Authors: Duan, Xiaojiang, Zhang, Xuran, Gan, Qianqian, Fang, Si'an, Ruan, Qing, Song, Xiaoqing, Zhang, Junbo
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2018
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071732/
https://ncbi.nlm.nih.gov/pubmed/30108961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00635g
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