A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor

We present herein a novel dissection-then-evolution strategy for ligand optimization. Using the co-crystal structure of the smoothened receptor (SMO) as a guide, we studied the modular contribution of LY2940680 by systematically “silencing” the specific interaction between the individual residue(s)...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Ye, Lintao, Ding, Kang, Zhao, Fei, Liu, Xiaoyan, Wu, Yiran, Liu, Yang, Xue, Dongxiang, Zhou, Fang, Zhang, Xianjun, Stevens, Raymond C., Xu, Fei, Zhao, Suwen, Tao, Houchao
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072208/
https://ncbi.nlm.nih.gov/pubmed/30108845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00104e
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