HCV NS5A dimer interface residues regulate HCV replication by controlling its self-interaction, hyperphosphorylation, subcellular localization and interaction with cyclophilin A

The HCV NS5A protein plays multiple roles during viral replication, including viral genome replication and virus particle assembly. The crystal structures of the NS5A N-terminal domain indicated the potential existence of the NS5A dimers formed via at least two or more distinct dimeric interfaces. H...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Shanmugam, Saravanabalaji, Nichols, Alyssa K., Saravanabalaji, Dhanaranjani, Welsch, Christoph, Yi, MinKyung
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072203/
https://ncbi.nlm.nih.gov/pubmed/30036383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007177
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