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ATM, ATR, CHK1, CHK2 and WEE1 inhibitors in cancer and cancer stem cells

DNA inevitably undergoes a high number of damages throughout the cell cycle. To preserve the integrity of the genome, cells have developed a complex enzymatic machinery aimed at sensing and repairing DNA lesions, pausing the cell cycle to provide more time to repair, or induce apoptosis if damages a...

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Vydáno v:Medchemcomm
Hlavní autoři: Ronco, Cyril, Martin, Anthony R., Demange, Luc, Benhida, Rachid
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072143/
https://ncbi.nlm.nih.gov/pubmed/30108746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00439c
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