A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants

In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold formed during wound healing, the type and composition of fibrin impacts the level of sprouting. More sprouts form on high molecular weight (HMW) than on low molecular weight (LMW) fibrin. It is unclear...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Boas, Sonja E. M., Carvalho, Joao, van den Broek, Marloes, Weijers, Ester M., Goumans, Marie-José, Koolwijk, Pieter, Merks, Roeland M. H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072121/
https://ncbi.nlm.nih.gov/pubmed/29979675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006239
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