A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants

In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold formed during wound healing, the type and composition of fibrin impacts the level of sprouting. More sprouts form on high molecular weight (HMW) than on low molecular weight (LMW) fibrin. It is unclear...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Comput Biol
Egile Nagusiak: Boas, Sonja E. M., Carvalho, Joao, van den Broek, Marloes, Weijers, Ester M., Goumans, Marie-José, Koolwijk, Pieter, Merks, Roeland M. H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2018
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072121/
https://ncbi.nlm.nih.gov/pubmed/29979675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006239
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