HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells

BACKGROUND: During short-term hypoxia, Hypoxia Inducible Factors (particular their subunits HIF-1α and HIF-2α) regulate the expression of many genes including the potent angiogenesis stimulator VEGF. However, in some pathological conditions chronic hypoxia occurs and is accompanied by reduced angiog...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nauta, Tessa D., Duyndam, Monique C. A., Weijers, Ester M., van Hinsbergh, Victor M. W., Koolwijk, Pieter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973926/
https://ncbi.nlm.nih.gov/pubmed/27490118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160700
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