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A marginalized two-part Beta regression model for microbiome compositional data

In microbiome studies, an important goal is to detect differential abundance of microbes across clinical conditions and treatment options. However, the microbiome compositional data (quantified by relative abundance) are highly skewed, bounded in [0, 1), and often have many zeros. A two-part model i...

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: Chai, Haitao, Jiang, Hongmei, Lin, Lu, Liu, Lei
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072097/
https://ncbi.nlm.nih.gov/pubmed/30036363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006329
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