Synthesis, molecular modeling and biological evaluation of aza-flavanones as α-glucosidase inhibitors

An efficient acid catalyzed methodology has been employed to synthesize a variety of aza-flavanones and their α-glucosidase inhibitory activity is evaluated using acarbose, miglitol and voglibose as reference standards. Molecular modeling studies were performed for all compounds to identify the impo...

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Publicado en:Medchemcomm
Autores principales: Kasturi, Sivaprasad, Surarapu, Sujatha, Bathoju, Chandra Chary, Uppalanchi, Srinivas, Dwivedi, Shubham, Perumal, Yogeeswari, Sigalapalli, Dilep Kumar, Babu, Bathini Nagendra, Ethiraj, Krishna S., Anireddy, Jaya Shree
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072087/
https://ncbi.nlm.nih.gov/pubmed/30108873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00162b
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