Design and synthesis of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone conjugates: study on their apoptosis inducing ability and tubulin polymerization inhibition

A library of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone derivatives were designed, synthesized and screened for their in vitro cytotoxic activity against BT-474, HeLa, MCF-7, NCI-H460 and HaCaT cells by employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromi...

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Detalhes bibliográficos
Publicado no:RSC Med Chem
Main Authors: Manasa, Kesari Lakshmi, Thatikonda, Sowjanya, Sigalapalli, Dilep Kumar, Vuppaladadium, Sowmya, Devi, Ganthala Parimala, Godugu, Chandraiah, Alvala, Mallika, Nagesh, Narayana, Babu, Bathini Nagendra
Formato: Artigo
Idioma:Inglês
Publicado em: RSC 2020
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126877/
https://ncbi.nlm.nih.gov/pubmed/34095841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00162g
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