Synthesis of novel pentacyclic triterpene–Neu5Ac2en derivatives and investigation of their in vitro anti-influenza entry activity

Sialic acid derivatives, analogs, and their conjugates are important pharmacophores. Modification of the C-4 hydroxyl group of sialic acid can lead to derivatives, such as zanamivir, with potent anti-influenza activities. Herein, we described the synthesis of C-4-modified sialic acid derivatives via...

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Veröffentlicht in:Medchemcomm
Hauptverfasser: Shi, Yongying, Si, Longlong, Han, Xu, Fan, Zibo, Wang, Shouxin, Li, Man, Sun, Jiaqi, Zhang, Yongmin, Zhou, Demin, Xiao, Sulong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2017
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072002/
https://ncbi.nlm.nih.gov/pubmed/30108865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00245a
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