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Exploring eukaryotic versus prokaryotic ribosomal RNA recognition with aminoglycoside derivatives
New derivatives of aminoglycosides containing 6′-carboxylic acid or 6′-amide on their ring I were designed, synthesized and their ability to readthrough nonsense mutations was examined in vitro, along with the protein translation inhibition in prokaryotic and eukaryotic systems. The observed structu...
Shranjeno v:
| izdano v: | Medchemcomm |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Royal Society of Chemistry
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071974/ https://ncbi.nlm.nih.gov/pubmed/30108940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00001h |
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