Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors

We report herein the design and synthesis of a series of 11 novel tacrine-1,2,3-triazole derivatives via a Cu(i)-catalyzed alkyne–azide 1,3-dipolar cycloaddition (CuAAC) reaction. The newly synthesized compounds were evaluated for their inhibition activity against Electrophorus electricus acetylchol...

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Vydáno v:Medchemcomm
Hlavní autoři: Wu, Gaochan, Gao, Yun, Kang, Dongwei, Huang, Boshi, Huo, Zhipeng, Liu, Huiqing, Poongavanam, Vasanthanathan, Zhan, Peng, Liu, Xinyong
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2017
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071962/
https://ncbi.nlm.nih.gov/pubmed/30108908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00457e
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