Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy

Herein we describe the discovery of a novel series of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators for the treatment of Alzheimer's disease (AD). Using ligand-based design tactics such as conformational analysis and molecular modeling, a cyclopropyl chromane unit...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Medchemcomm
Päätekijät: Pettersson, Martin, Johnson, Douglas S., Rankic, Danica A., Kauffman, Gregory W., am Ende, Christopher W., Butler, Todd W., Boscoe, Brian, Evrard, Edelweiss, Helal, Christopher J., Humphrey, John M., Stepan, Antonia F., Stiff, Cory M., Yang, Eddie, Xie, Longfei, Bales, Kelly R., Hajos-Korcsok, Eva, Jenkinson, Stephen, Pettersen, Betty, Pustilnik, Leslie R., Ramirez, David S., Steyn, Stefanus J., Wood, Kathleen M., Verhoest, Patrick R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Royal Society of Chemistry 2016
Aiheet:
Chemistry
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071960/
https://ncbi.nlm.nih.gov/pubmed/30108792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00406g
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia