Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability

Por Pettersson, Martin, Johnson, Douglas S., Humphrey, John M., Butler, Todd W., am Ende, Christopher W., Fish, Benjamin A., Green, Michael E., Kauffman, Gregory W., Mullins, Patrick B., O’Donnell, Christopher J., Stepan, Antonia F., Stiff, Cory M., Subramanyam, Chakrapani, Tran, Tuan P., Vetelino, Beth Cooper, Yang, Eddie, Xie, Longfei, Bales, Kelly R., Pustilnik, Leslie R., Steyn, Stefanus J., Wood, Kathleen M., Verhoest, Patrick R.
Publicado no ACS Med Chem Lett (2015)

Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy

Por Pettersson, Martin, Johnson, Douglas S., Rankic, Danica A., Kauffman, Gregory W., am Ende, Christopher W., Butler, Todd W., Boscoe, Brian, Evrard, Edelweiss, Helal, Christopher J., Humphrey, John M., Stepan, Antonia F., Stiff, Cory M., Yang, Eddie, Xie, Longfei, Bales, Kelly R., Hajos-Korcsok, Eva, Jenkinson, Stephen, Pettersen, Betty, Pustilnik, Leslie R., Ramirez, David S., Steyn, Stefanus J., Wood, Kathleen M., Verhoest, Patrick R.
Publicado no Medchemcomm (2016)