Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy

Herein we describe the discovery of a novel series of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators for the treatment of Alzheimer's disease (AD). Using ligand-based design tactics such as conformational analysis and molecular modeling, a cyclopropyl chromane unit...

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Publicado no:Medchemcomm
Main Authors: Pettersson, Martin, Johnson, Douglas S., Rankic, Danica A., Kauffman, Gregory W., am Ende, Christopher W., Butler, Todd W., Boscoe, Brian, Evrard, Edelweiss, Helal, Christopher J., Humphrey, John M., Stepan, Antonia F., Stiff, Cory M., Yang, Eddie, Xie, Longfei, Bales, Kelly R., Hajos-Korcsok, Eva, Jenkinson, Stephen, Pettersen, Betty, Pustilnik, Leslie R., Ramirez, David S., Steyn, Stefanus J., Wood, Kathleen M., Verhoest, Patrick R.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071960/
https://ncbi.nlm.nih.gov/pubmed/30108792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00406g
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