Multivalent ligands for the serotonin 5-HT(4) receptor

5-HT(4) receptors are known to form constitutive dimers in membranes. To explore whether multivalency can enhance ligand interactions and/or efficacy in 5-HT(4) receptors, the structure of the partial agonist ML10302 was modified with oligo(ethylene glycol) chains, thus generating, by a gradual appr...

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Publicado en:Medchemcomm
Autores principales: Castriconi, Federica, Paolino, Marco, Donati, Alessandro, Giuliani, Germano, Anzini, Maurizio, Mennuni, Laura, Sabatini, Chiara, Lanza, Marco, Caselli, Gianfranco, Makovec, Francesco, Sbraccia, Maria, Molinari, Paola, Costa, Tommaso, Cappelli, Andrea
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071950/
https://ncbi.nlm.nih.gov/pubmed/30108781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00458j
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