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Multivalent ligands for the serotonin 5-HT(4) receptor
5-HT(4) receptors are known to form constitutive dimers in membranes. To explore whether multivalency can enhance ligand interactions and/or efficacy in 5-HT(4) receptors, the structure of the partial agonist ML10302 was modified with oligo(ethylene glycol) chains, thus generating, by a gradual appr...
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| 出版年: | Medchemcomm |
|---|---|
| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Royal Society of Chemistry
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071950/ https://ncbi.nlm.nih.gov/pubmed/30108781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00458j |
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