Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type–Specific Enhancer Activation and Gene Expression

BACKGROUND: Cigarette smoke is a causal factor in cancers and cardiovascular disease. Smoking-associated differentially methylated regions (SM-DMRs) have been observed in disease studies, but the causal link between altered DNA methylation and transcriptional change is obscure. OBJECTIVE: Our object...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Environ Health Perspect
Main Authors: Wan, Ma, Bennett, Brian D., Pittman, Gary S., Campbell, Michelle R., Reynolds, Lindsay M., Porter, Devin K., Crowl, Christopher L., Wang, Xuting, Su, Dan, Englert, Neal A., Thompson, Isabel J., Liu, Yongmei, Bell, Douglas A.
פורמט: Artigo
שפה:Inglês
יצא לאור: Environmental Health Perspectives 2018
נושאים:
Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071796/
https://ncbi.nlm.nih.gov/pubmed/29706059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP2395
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