Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type–Specific Enhancer Activation and Gene Expression

BACKGROUND: Cigarette smoke is a causal factor in cancers and cardiovascular disease. Smoking-associated differentially methylated regions (SM-DMRs) have been observed in disease studies, but the causal link between altered DNA methylation and transcriptional change is obscure. OBJECTIVE: Our object...

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Detalhes bibliográficos
Publicado no:Environ Health Perspect
Main Authors: Wan, Ma, Bennett, Brian D., Pittman, Gary S., Campbell, Michelle R., Reynolds, Lindsay M., Porter, Devin K., Crowl, Christopher L., Wang, Xuting, Su, Dan, Englert, Neal A., Thompson, Isabel J., Liu, Yongmei, Bell, Douglas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Environmental Health Perspectives 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071796/
https://ncbi.nlm.nih.gov/pubmed/29706059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP2395
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