DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations with Cigarette Smoking and Subclinical Atherosclerosis

BACKGROUND: Tobacco smoke contains numerous agonists of the aryl-hydrocarbon receptor (AhR) pathway, and activation of the AhR pathway was shown to promote atherosclerosis in mice. Intriguingly, cigarette smoking is most strongly and robustly associated with DNA modifications to an AhR pathway gene,...

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Publicado no:Circ Cardiovasc Genet
Main Authors: Reynolds, Lindsay M., Wan, Ma, Ding, Jingzhong, Taylor, Jackson R., Mstat, Kurt Lohman, Su, Dan, Bennett, Brian D., Porter, Devin K., Gimple, Ryan, Pittman, Gary S., Wang, Xuting, Howard, Timothy D., Siscovick, David, Psaty, Bruce M., Shea, Steven, Burke, Gregory L., Jacobs, David R., Rich, Stephen S., Hixson, James E., Stein, James H., Stunnenberg, Hendrik, Barr, R. Graham, Kaufman, Joel D., Post, Wendy S., Hoeschele, Ina, Herrington, David M., Bell, Douglas A., Liu, Yongmei
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618776/
https://ncbi.nlm.nih.gov/pubmed/26307030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.115.001097
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