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Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer
ALK-fusion proteins play a fundamental role in the development of about 5% of non-small cell lung cancers. Herein, we identified the compound 5067-0952 as a potent ALK inhibitor, which inhibited cell growth, induced apoptosis, and suppressed the phosphorylation of ALK, subsequently blocking its down...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071718/ https://ncbi.nlm.nih.gov/pubmed/30108712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00305f |
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