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Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer

ALK-fusion proteins play a fundamental role in the development of about 5% of non-small cell lung cancers. Herein, we identified the compound 5067-0952 as a potent ALK inhibitor, which inhibited cell growth, induced apoptosis, and suppressed the phosphorylation of ALK, subsequently blocking its down...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Luo, Lian-Xiang, Li, Ying, Niu, Yu-Zhen, Wang, Yu-Wei, Wang, Qian-Qian, Fan, Xing-Xing, Xu, Jia-Hui, Liu, Liang, Leung, Elaine Lai-Han, Yao, Xiao-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071718/
https://ncbi.nlm.nih.gov/pubmed/30108712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00305f
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