EPH receptor signaling as a novel therapeutic target in NF2-deficient meningioma

BACKGROUND: Meningiomas are the most common primary brain tumor in adults, and somatic loss of the neurofibromatosis 2 (NF2) tumor suppressor gene is a frequent genetic event. There is no effective treatment for tumors that recur or continue to grow despite surgery and/or radiation. Therefore, targe...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Angus, Steven P, Oblinger, Janet L, Stuhlmiller, Timothy J, DeSouza, Patrick A, Beauchamp, Roberta L, Witt, Luke, Chen, Xin, Jordan, Justin T, Gilbert, Thomas S K, Stemmer-Rachamimov, Anat, Gusella, James F, Plotkin, Scott R, Haggarty, Stephen J, Chang, Long-Sheng, Johnson, Gary L, Ramesh, Vijaya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071664/
https://ncbi.nlm.nih.gov/pubmed/29982664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy046
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