USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism

Ras mutations are commonly observed in juvenile myelomonocytic leukemia (JMML) and chronic myelomonocytic leukemia (CMML). JMML and CMML transform into acute myeloid leukemia (AML) in about 10% and 50% of patients, respectively. However, how additional events cooperate with Ras to promote this trans...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Melo-Cardenas, Johanna, Xu, Yuanming, Wei, Juncheng, Tan, Can, Kong, Sinyi, Gao, Beixue, Montauti, Elena, Kirsammer, Gina, Licht, Jonathan D., Yu, Jindan, Ji, Peng, Crispino, John D., Fang, Deyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071563/
https://ncbi.nlm.nih.gov/pubmed/29844011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-10-811760
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