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Vpr targets TET2 for degradation by CRL4(VprBP) E3 ligase to sustain IL-6 expression and enhance HIV-1 replication

HIV-1 expresses several accessory proteins to counteract host anti-viral restriction factors to facilitate viral replication and disease progression. One such protein, Vpr, has been implicated in affecting multiple cellular processes, but its mechanism remains elusive. Here we report that Vpr target...

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Bibliografische gegevens
Gepubliceerd in:Mol Cell
Hoofdauteurs: Lv, Lei, Wang, Qi, Xu, Yanping, Tsao, Li-Chung, Nakagawa, Tadashi, Guo, Haitao, Su, Lishan, Xiong, Yue
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071318/
https://ncbi.nlm.nih.gov/pubmed/29883611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.05.007
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