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Vpr targets TET2 for degradation by CRL4(VprBP) E3 ligase to sustain IL-6 expression and enhance HIV-1 replication

HIV-1 expresses several accessory proteins to counteract host anti-viral restriction factors to facilitate viral replication and disease progression. One such protein, Vpr, has been implicated in affecting multiple cellular processes, but its mechanism remains elusive. Here we report that Vpr target...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Lv, Lei, Wang, Qi, Xu, Yanping, Tsao, Li-Chung, Nakagawa, Tadashi, Guo, Haitao, Su, Lishan, Xiong, Yue
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071318/
https://ncbi.nlm.nih.gov/pubmed/29883611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.05.007
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